This supports the concept of discorrelation, inappropriate timing of
information, and deterioration of various parts of the brain due to this.
Unfortunately the model of Correlational Opponent Processing does not
immediately suggest procedures for helping.
----- Original Message -----
Sent: Sunday, October 31, 1999 7:40
PM
Subject: Is the 'normal' range of this
continuum related to 'paranormal perceptions" ?
Acta Psychiatr Scand Suppl 1999;395:80-8
Cortical brain dysfunction in early schizophrenia: secondary
pathogenetic hierarchy of neuroplasticity, psychopathology
and social
impairment.
Hemmingsen R, Madsen A, Glenthoj B, Rubin P
Department of Psychiatry E, Bispebjerg Hospital, University of Copenhagen,
Denmark.
Schizophrenia has the quality of a 'top-down' disorder with perturbation of
self, and malattuned
appraisal of basic experience of the outside world,
and of intentionality. There is dissonance
between the faculties of
consciousness. The neuronal cortical network displays distributed
activation of the sensory cortices during perception, and retroactivation
during recall. This
multimodal organization is sensitive to aberrations of
structure and informational content during
the metabolically dynamic
phases of expansion and pruning in childhood and adolescence. There
is
substantial evidence of deviant function of the cortical network in
schizophrenia. This includes
increased neuronal density, reduced
prefrontal capacity for activation, impaired fronto-temporal
interaction
during language production, defect monitoring of inner speech, activation of
secondary sensory cortices during hallucinations, reduced cortical and
thalamic volume, reduced
thalamic activation (filtering) and sensitization
of dopaminergic modulation. As a hypothesis the
cortical defects lead to
secondary causation of abnormalities at the levels of neuroplasticity,
symptomatology and social competence. Suggestions for empirical testing
are presented for the
hypothesis that neocortical defects are primary,
thalamic defects secondary and dopaminergic
aberrations tertiary in the
schizophrenic process. This testing of hypotheses involves prospective
studies of patient groups at various ages of onset, as well as comparison
of neurobiological
measures in remitting vs. treatment-resistant cases.
PMID: 10225336, UI: 99239842
