On Wed, 1 Mar 2000, Dani' Raap wrote:
> Hi all - I have a group of intro students interested in doing a project
> on Narcolepsy.
> 1) I have a few references from by physio texts, but wondering if there
> was anyone out there that had suggestions on more complete sources for
> info on narcolepsy, cataplexy, use of dogs as a model, etc...
There's a recent news item in Science on identifying genes for
narcolepsy (Takahashi, 1999). It turns out that the genes code for
a receptor which binds the neurochemical orexin. Orexin is itself a
hot topic these days, as it acts in the hypothalamus to stimulate
food intake. It's beginning to look like everything is connected to
everything, isn't it?
Science has a website on the topic at
www.sciencemag.org/feature/data/1045064.shl
with some movies showing narcolepsy (but I fell asleep waiting for
them to load).
>
> 2) Does anyone know if Aldrich is still at Stanford/still doing
> narcolepsy research?
No references to Aldrich in the item. I'd like to know more about his
work. Care to enlighten us, Dani'?
Reference and a short biblio
Takahashi, J. (1999). Narcolepsy genes wake up the sleep field.
Science, 285, 2076--
Chemelli, R. and a bunch of others (1999). Narcolepsy in orexin
knockout mice: molecular genetics of sleep regulation. Cell,
98, 437-51
Lin, L. and another bunch (1999). The sleep disorder canine narcolepsy
is caused by a mutation in the hypocretic (orexin) receptor 2 gene.
Cell, 98, 365-76.
-Stephen
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Stephen Black, Ph.D. tel: (819) 822-9600 ext 2470
Department of Psychology fax: (819) 822-9661
Bishop's University e-mail: [EMAIL PROTECTED]
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Canada Department web page at http://www.ubishops.ca/ccc/div/soc/psy
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