The NY Times had an article this week on a PLoS Biology
article that reported that examination of cells of the fruit fly
revealed:

(1) the gender/sex of the fruit fly "cell" is determined
by the expression of genes called "doublesex" and "fruitless"
which, when expressed one way reflects male and when 
expressed another way reflects females

(2) this leads to the idea that at the cellualr level, cells
"know" that they are either male or female but the 
surprising thing is that there are cells that are neither
male of female, that is, doublesex/fruitless apparently is not
"turned on" to be either sex. One way to think about
this is that the cell doesn't know if is male or female.

The notion that gender/sex is expressed at the cellular
level of the fruit fly raises questions of how common
this might be in other species, including humans.

This situation can lead to a variety of speculations such
as how does a "female" heart (i.e., cells of the heart tuned
to be female) differ from a "male" heart?  What happens
when a male gets a female heart in a transplant?  Will
it affect their behavior is subtle ways?  Will it make them
more compassionate?  Better listeners? Obsessive over
shoes?

For the brief NY Times article, see:
http://www.nytimes.com/2010/05/11/science/11obflies.html?ref=science
For the PLoS Biology article, see:
http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000365

-Mike Palij
New York University
[email protected]




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