That is a stunning and very depressing comment.
Ken > On Sep 17, 2015, at 5:53 PM, Christopher Green <[email protected]> wrote: > > > > > > > In the immortal words of Richard W. Smith, longtime editor of the British > Medical Journal, "Medical journals are an extension of the marketing arm of > pharmaceutical companies” (PLoS Med, 2005). > > It’s a pity that he kept that information to himself during the 25 years he > worked for the journal, only letting the cat out of the bag after he was out > the door. > > Chris > ….. > Christopher D Green > Department of Psychology > York University > Toronto, ON M3J 1P3 > Canada > 43.773897°, -79.503667° > > [email protected] <mailto:[email protected]> > http://www.yorku.ca/christo <http://www.yorku.ca/christo> > ………………………………... > > On Sep 17, 2015, at 4:50 PM, Mike Palij <[email protected] <mailto:[email protected]>> > wrote: > >> In 2001 the "Journal of the Academy of Child and Adolescent >> Psychiatry" published a research study on the treatment of depression >> in adolescents, randomized control trial (RCT) which had groups >> that received paroxetine, imipramine, or placebo -- this study >> is also known as "Study 329". In that article it was claimed that >> paroxetine was effective and safe to use with adolescents. At that >> time there were those who questioned the research design and >> the results but the marketing of paroxetine (by the company now >> known as GlaxoSmithKline or GSK) made it widely used. >> >> Critics of the Study 329 were able to get the original data and >> documents and they completed and published a re-analysis of >> the data which was just published in the British Medical Journal >> or BMJ. The main conclusion: one the primary measure of >> depression, the three groups did not differ after 8 weeks of >> treatment (i.e., paroxetine vs imipramine vs placebo). No >> effect at all. However, the paroxetine group showed increased >> suicidal ideation and behavior while the imipramine group showed >> cardiovascular problems. As you might imagine, all hell has >> broken loose as a result. The popular media has picked up >> on this story and one source is (you guessed it) the New York >> Times; see: >> http://www.nytimes.com/2015/09/17/health/antidepressant-paxil-is-unsafe-for-teenagers-new-analysis-says.html?_r=0 >> >> <http://www.nytimes.com/2015/09/17/health/antidepressant-paxil-is-unsafe-for-teenagers-new-analysis-says.html?_r=0> >> >> The re-analysis is available on the BMJ website; see: >> http://www.bmj.com/content/351/bmj.h4320 >> >> The BMJ also has an editorial that highlights some of the research >> and ethical problems associated with the research and those >> who were involved in the origin study; see: >> http://www.bmj.com/content/351/bmj.h4629 >> >> The title of the editorial is: >> No correction, no retraction, no apology, no comment: paroxetine >> trial reanalysis raises questions about institutional responsibility >> >> I think this study beats Milgram and Zimbardo in the unethical department. >> >> -Mike Palij >> New York University >> [email protected] >> >> P.S. I find the following sentence from the editorial both frightening >> and hilarious: >> >> |The first draft of the manuscript ultimately published in the >> |Journal of the American Academy of Child and Adolescent >> |Psychiatry (JAACAP) was not written by any of the 22 named >> |authors but by an outside medical writer hired by GSK. . >> >> There were 22 authors and the paper was originally written >> by a medical writer who probably didn't even get an authorship >> credit. >> >> >> --- >> You are currently subscribed to tips as: [email protected]. >> To unsubscribe click here: >> http://fsulist.frostburg.edu/u?id=430248.781165b5ef80a3cd2b14721caf62bd92&n=T&l=tips&o=46811 >> or send a blank email to >> leave-46811-430248.781165b5ef80a3cd2b14721caf62b...@fsulist.frostburg.edu > > --- > > You are currently subscribed to tips as: [email protected] > <mailto:[email protected]>. > > To unsubscribe click here: > http://fsulist.frostburg.edu/u?id=13524.94845a3ed9806f1cef14973830dd8c39&n=T&l=tips&o=46813 > > <http://fsulist.frostburg.edu/u?id=13524.94845a3ed9806f1cef14973830dd8c39&n=T&l=tips&o=46813> > (It may be necessary to cut and paste the above URL if the line is broken) > > or send a blank email to > leave-46813-13524.94845a3ed9806f1cef14973830dd8...@fsulist.frostburg.edu > <mailto:leave-46813-13524.94845a3ed9806f1cef14973830dd8...@fsulist.frostburg.edu> > > > > --- You are currently subscribed to tips as: [email protected]. To unsubscribe click here: http://fsulist.frostburg.edu/u?id=13090.68da6e6e5325aa33287ff385b70df5d5&n=T&l=tips&o=46814 or send a blank email to leave-46814-13090.68da6e6e5325aa33287ff385b70df...@fsulist.frostburg.edu
