AS I WROTE THAT, I THOUGHT I USED THE WORD 'USUALLY' AND NOW SEE THAT I WAS NOT THAT CLEAR. TM IS LIMITED TO THE SPINAL CORD, AS FAR AS I KNOW, MS CAN OCCUR ANYWHERE IN THE CNS, BUT IS USUALLY IN THE BRAIN OR STEM. SOME WOULD ARGUE THIS POINT, BUT FOR PURPOSES OF A SIMPLE EXPLANATION, TM IS IN THE SPINAL CORD AND MS IN THE BRAIN.
I DID SAY THAT BOTH TM AND MS ARE DEMYELINATING. ONE OCCURS IN MULTIPLE LOCATIONS AND THE OTHER IN ONE, HERE, AGAIN, USUALLY. IT'S LIKE ENGRISH, IT HAS ALL SORTS OF EXCEPTIONS, I BEFORE E EXCEPT AFTER ?
I PREFER TO NOT ELUCIDATE ON SPECIFICS, BUT IN GENERALITIES. TO BE SPECIFIC, IT COULD GET A BIT CONFUSING AND THE TERMINOLOGY MOST DIFFICULT. WHITE MATTER VS, GREY MATTER, CORPUS COLOSSUM, PARIETAL OR CENTRAL, OR MEDULLA, ETC.
----- Original Message -----
To: [EMAIL PROTECTED]
Sent: 10/12/2005 5:23:22 PM
Subject: Re: [TMIC] Hello
Bob, there's a lot of misinformation out there and one erroneous fact is that MS is only in the brain. Actually, demyelation can occur in the spinal cord as well as the brain. Hope you don't mind my setting that straight.
Diane in Canada
ROBERT COOK wrote:
I AM NOT SURE WHY ANYONE THAT HAS TM IS MORE SUSCEPTIBLE TO COMING DOWN WITH MS, BUT FROM READING A RECENT ARTICLE IT IS THOUGHT TAT TM AND OTHER IMMUNONEUROLOGICAL DISORDERS MIGHT BE GENETICALLY LINKED. THE RESEARCHERS ARE NOT SURE OF THAT YET, BUT THERE ARE SOME INDICATIONS OF THAT. BOTH ARE DEMYELINATING BUT ARE USUALLY DIFFERING IN THAT TM IS IN THE SPINAL CORD AND MS IN THE BRAIN. WHAT PERCENTAGE OF TM'ERS GOES ON TO HAVE MS, I DO NOT KNOW, BUT IT IS NOT A FREQUENT RESULT. FROM WHAT I HAVE SEEN ON THE TMIC LIST, I WOULD GUESS ABOUT TEN PERCENT? OR LESS. THE WHY, IS YOUR QUESTION, AND THERE IS NO CONCRETE ANSWER. A LONG ANALYSIS ON THE POSSIBLE EXPLANATION IS MADE IN MOST TECHNICAL TERMS AT: http://www.jci.org/cgi/content/full/115/10/2731 IT SEEMS THAT A BAD BOY BY THE NAME IF 'IL-6' !
IS INVOLVED IN THE CAUSE OF BOTH TM AND MS, COUPLED WITH THE INORDINATE ABUNDANCE OF POTASSIUM THAT BLOCKS NERVE TRANSMISSION, AND THE TWO TOGETHER DESTROYS THE INSULATION AROUND THE NERVE AXONS. THIS IS MOSTLY COMMON WHEN THE INITIATING FACTOR CAUSING TM IS UNKNOWN. IT TAKES SOMETHING TO TRIGGER THE WHOLE MESS TO START WITH. IT IS NOT REALLY KNOWN IF KNOWN TRIGGERS LIKE A FLU JAB, THE ACTUAL FLU OR OTHER SUSPECTED TRIGGERS CAN GO ON TO BECOME MS, OR NOT. IT IS ALL A BUNCH OF 'GOBBDLY-GOOK', EVEN TO THE DOCTORS RIGHT NOW. MAYBE THEY WILL GET IT ALL SORTED OUT ONE DAY, DEVELOPING TECHNOLOGY IS GROWING FAST AND HOPEFULLY THE CURE WILL COME WITH IT. MY GUESS IS THAT IF HE HAS GONE THIS LONG, HE SHOULD NOT-NOR SHOULD YOU- WORRY ALL THAT MUCH ABOUT IT. THE ONES I'VE SEEN HAPPEN MUCH SOONER AFTER THE INITIAL TM ATTACK. BOB FROM HOUSTON-SPRING, TX |
