Hello Nima:  I am on Tizanidine and Lyrica. Both seem to work ok. 
Remember, I am not a doctor, so cannot give medical advice.
I see several factors at work here:
  All medicines have side effects. One of Tizanidine's is drowsiness. So
is Lyrica.  I take naps after medication time so I can function.

  As we deal with our cluster of symptoms, we have to compensate for our
deficiencies by overworking other parts, thus causing more problems.

  I see others on the list who regularly see a physiatrist to evaluate
their functioning and suggest exercises and ways to strengthen and
improve physical functioning.

  Be sure to let the doctor know about these problems!  Be an advocate for
him!  Don't take no for an answer.  And with everything else that is
going on--is he being treated for depression?  TM has the highest
coincidence of depression of any disease, including MS.

Hooray for you looking for answers!


> Hi Everybody
>
> A lot has been said about Lyrica and before that about Baclofen. I would
> like to clarify these points.
>
>   a.. Those who are taking Lyrica are you on any other medication like
> Baclofen or Tizanidine or Zanaflex?
>   b.. My husband Dev was put on Baclofen and Tizanidine. He started
> getting very tired. His left leg is very weak he cannot use it. He does
> regular physiotherapy but now he feels his right leg is getting weak. Is
> it fatigue?
>   c.. He is using a walker at the moment and all the weight is borne by
> his arms so his arms get tired and at times he gets blisters on his
> palms. Will it be harmful or dangerous to his upper body if this goes
> on?
>   d.. His back jams up at night. He is feeling a lot of pain lately. So he
> was put on Lyrica. Is this usual with TM?
>
> These symptoms are coming now. Initially there was no pain (only burning),
> no spasms, his legs were almost ok and his balance had come back 70% but
> now after 1 1/2 year it is getting worse. Yet all the tests, MRI  and
> scans prove there is no further demyelination of the nerves and his VEP
> and BERM (sight and hearing evoked potential tests) are normal so MS is
> ruled out.
>
> I was under the impression that TM is one time attatck it doesn't get
> worse, there is only residual effect of TM.
> So is his condition getting worse because of
> TM getting worse
> or due to taking Baclofen
> or overstraining of muscles
> or what???????
>
> Hope someone has some answers for me
>
> Dev's love of life
> Nima
> from Kenyan coast
>


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