New blood thinner may negate bleeding risk NEW ORLEANS, -- U.S. cardiologists have determined a new blood thinner might significantly reduce the risk of heart attack and stroke without the risk of bleeding. Blood thinners now being used to prevent blood clots that are the leading cause of heart attack and stroke also pose a risk of major bleeding. But the cardiovascular chief at the University of Kentucky College of Medicine, Dr. David Moliterno, said a study has found a new blood thinner drug, called a thrombin-receptor antagonist, or TRA, prevents clotting but does not produce excessive bleeding. TRA was given in addition to established anti- clotting drugs to 1,030 patients undergoing cardiac cathe- terization and related intervention at 77 sites in six nations. A 46 percent reduction in serious cardiovascular events was noted, without increased bleeding. "We were surprised by the extent of benefit," said Moliterno. "These results are so noteworthy because the study demonstrated that this first-in-class TRA did not increase bleeding at all in a group of patients that is certainly at risk. And honestly, therefore, we did not expect to see a large benefit." Moliterno presented the study during the weekend in New Orleans during the American College of Cardiology's annual meeting.
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