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<http://rockcreekfreepress.tumblr.com/post/35324640/aspartame-sweet-but-dang
erous> Aspartame: Sweet But Dangerous


BY ELAINE SULLIVAN / RCFP

Aspartame is one of the most controversial food additives in history.
Aspartame, a combination of two amino acids phenylalanine and aspartic acid,
is sold commercially under names like Nutrasweet, Equal and Candereal, and
can be found in more than 5,000 foods, including sodas, chewing gum,
tabletop sweeteners, diet and diabetic foods, breakfast cereals, jams,
sweets, vitamins, prescription and over-the-counter drugs. Approximately 2/3
of the adult population and 1/3 of children regularly ingest this artificial
sweetener. Aspartame was approved as a food additive by the Food and Drug
Administration (FDA) in 1981, but the debate about its safety continues.

Aspartame chemistryAspartame was discovered by a chemist working at the
pharmaceutical manufacturer GD Searle in December 1965. Searle began safety
tests for FDA approval in 1967. The first study conducted by Dr. Harry
Waisman, director of the University of Wisconsin's Joseph P. Kennedy Jr.
Memorial Laboratory of Mental Retardation Research and a respected expert in
the toxicity of phenylalanine, studied the effects of aspartame on primates.
Of seven monkeys fed aspartame mixed with milk, one died and five others had
grand mal epileptic seizures. Dr. John Olney, professor of neuropathology
and psychiatry at Washington University in St. Louis School of Medicine
informed Searle in 1971 that his studies show that aspartic acid, one of the
main components of aspartame causes holes in the brains of infant mice. This
is confirmed by one of Searle's own researchers, Ann Reynolds.

In spite of negative results, in 1973 Searle applied for FDA approval and
submitted studies claiming aspartame to be safe, with no mention of the dead
monkeys or the holes in the brains of the mice. From 1973 to the present
numerous studies by independent researchers have found not only that
aspartame is unsafe but that Searle's research has been faulty, at best. An
FDA task force concluded in a 1976 report that they found "faulty and
fraudulent product testing, knowingly misrepresented product testing,
knowingly misrepresented and manipulated test data and instances of
irrelevant animal research in all the products reviewed." FDA commissioner
Dr. Alexander Schmidt stated "Searle's studies were incredibly sloppy
science. What we discovered was reprehensible."

But this did not stop Searle from continuing to try to push aspartame
through the FDA approval process.

In 1977, for the first time in the FDA's history, it requested a criminal
investigation of a manufacturer. The FDA chief counsel Richard Merrill
formally requested the US Attorney's office to begin grand jury proceeding
against Searle. While the grand jury investigation was underway, Sidley &
Austin, the law firm representing Searle, began recruitment negotiations
with Samuel Skinner, the US attorney in charge of the investigation. Skinner
removed himself from the investigation, and was hired by Searle's law firm
six months later. Other conflicts of interest have followed including the
hiring of Donald Rumsfeld who used political favors to help push through
approval of aspartame. In 1981, as a member of the Reagan transition team
Rumsfeld was instrumental in promoting Dr. Arthur Hull Hayes, Jr. to the
post of FDA commissioner. Hayes then ignored the recommendations of his own
internal FDA team and gave initial approval for aspartame to be used in dry
products.

The FDA website gives aspartame only two short paragraphs and states: "To
date, FDA has not determined any consistent pattern of symptoms that can be
attributed to the use of aspartame, nor is the agency aware of any recent
studies that clearly show safety problems." Yet, an April, 1995 report by
the Dept. of Health and Human Services reports that the FDA received almost
10,000 complaints attributed to aspartame, enumerating 92 different side
effects. These side effects include: headache, dizziness, change in mood,
vomiting, abdominal pain/ cramps, change in vision, diarrhea, seizures and
convulsions, memory loss, and fatigue, to name just the top ten.

A quick search on "aspartame" on the website www.pubmedcentral.nih.gov will
provide a researcher with a long list of articles about the health effects
of aspartame. One of these articles is "Life-Span Exposure to Low Doses of
Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats",
by Morando Soffritti, Fiorella Belppoggi, et al. in Environmental Health
Perspective, 2007 September; 115(9): 1293-1297. This article is the result
of a second study to better quantify the carcinogenic risk of aspartame. The
researchers concluded that the results of the study confirmed and reinforced
the first experimental demonstration of aspartame's ".multipotential
carcinogenicity at a dose close to the acceptable daily intake for humans.
Futhermore, the study demonstrates that when life-span exposure to aspartame
begins during fetal life, its carcinogenic effects are increased." The last
paragraph of this article reads; "On the basis of the present findings, we
believe that a review of the current regulations governing the use of
aspartame cannot be delayed. This review is particularly urgent with regard
to aspartamecontaining beverages, which are heavily consumed by children."

Aspartame proponents consistently gloss over or out right ignore any studies
showing adverse health effects from aspartame. Even in the medical journals,
you will find researchers defending aspartame. In a response to the
Soffritti article, Eyassu Abegaz wrote in "Apartame Not Linked to Cancer",
that "The study by Soffritte et al. (2006) has major flaws that bring into
question the validity of the findings." But the beginnings of the two
articles may shed some light on the disagreement. The Soffritti article
states that "The authors declare they have no competing financial
interests." The Abegaz article, on the other hand, states that "The author
is emploed by Ajinomoto USA, which sells aspartame."

So the fight continues. Aspartame was approved by the FDA in 1981 and is
with us still today but the process has been full of fraudulent research,
conflicts of interest and manipulation of the political process. The FDA has
demonstrated once again that they are more interested in the financial
health of the drug companies than the health and well being of the American
people.

Elaine Sullivan is health editor for the Rock Creek Free Press in
Washington, DC.

For more information: "Aspartame - The Shocking Story of the World's
Bestselling Sweetener", The Ecologist, by Pat Thomas, September 2005  

 

 

 

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