From: Gary Kohls [mailto:[email protected]] 
Sent: Thursday, August 06, 2009 6:21 PM
To: Gary Kohls
Subject: A very important article on the cause of Autism (and probably many
other neurologic/mental illnesses): Proof that Thimerosal causes
neurotoxicity indistinguishable from autism spectrum disorders

 

 

http://articles.mercola.com/sites/articles/archive/2009/08/06/Proof-That-Thi
merosal-Induces-AutismLike-Neurotoxicity.aspx

_______________________________________________________________________

And for the abstract of the scientific article click on:
http://www.informaworld.com/smpp/content~content=a910652305~db=all~jumptype=
rss

_______________________________________________________________________


Mitochondrial dysfunction, impaired oxidative-reduction activity,
degeneration, and death in human neuronal and fetal cells induced by
low-level exposure to thimerosal and other metal compounds 


Authors: D. A. Geier a;  P. G. King b; M. R. Geier c 


Affiliations:   

a Institute of Chronic Illnesses, Inc., Maryland, USA

        
b CoMeD, Inc., Maryland, USA

        
c The Genetic Centers of America, Maryland, USA

DOI: 10.1080/02772240802246458 

Publication Frequency: 8 issues per year 

Published in: journalToxicological
<http://www.informaworld.com/smpp/title~db=all~content=t713653210> &
Environmental Chemistry, Volume 91
<http://www.informaworld.com/smpp/title~db=all~content=t713653210~tab=issues
list~branches=91#v91> , Issue 4
<http://www.informaworld.com/smpp/title~db=all~content=g912372338> June 2009
, pages 735 - 749 

First Published: June 2009 

Subjects: Chemistry
<http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~appen
d=714595176,714595177#subject714595177> ; Environmental
<http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~appen
d=714594144,714594094,714594148#subject714594148> & Ecological Toxicology;
Environmental Health
<http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~appen
d=738534356,714594347,911706806#subject911706806> ; Environmental Sciences
<http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~appen
d=714593598,714593678#subject714593678> ; Pollution
<http://www.informaworld.com/smpp/browse~db=all~thing=title~by=subject~appen
d=714593678,714593598,738553736#subject738553736> ; 

Previously published as: Toxicological & Environmental Chemistry Reviews
(0092-9867) until 1980 

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Full text options: no full text options are available. 

 



Abstract 


Thimerosal (ethylmercurithiosalicylic acid), an ethylmercury
(EtHg)-releasing compound (49.55% mercury (Hg)), was used in a range of
medical products for more than 70 years. Of particular recent concern,
routine administering of Thimerosal-containing biologics/childhood vaccines
have become significant sources of Hg exposure for some fetuses/infants.
This study was undertaken to investigate cellular damage among in vitro
human neuronal (SH-SY-5Y neuroblastoma and 1321N1 astrocytoma) and fetal
(nontransformed) model systems using cell vitality assays and
microscope-based digital image capture techniques to assess potential damage
induced by Thimerosal and other metal compounds (aluminum (Al) sulfate, lead
(Pb)(II) acetate, methylmercury (MeHg) hydroxide, and mercury (Hg)(II)
chloride) where the cation was reported to exert adverse effects on
developing cells. Thimerosal-associated cellular damage was also evaluated
for similarity to pathophysiological findings observed in patients diagnosed
with autistic disorders (ADs). Thimerosal-induced cellular damage as
evidenced by concentration- and time-dependent mitochondrial damage, reduced
oxidative-reduction activity, cellular degeneration, and cell death in the
in vitro human neuronal and fetal model systems studied. Thimerosal at low
nanomolar (nM) concentrations induced significant cellular toxicity in human
neuronal and fetal cells. Thimerosal-induced cytoxicity is similar to that
observed in AD pathophysiologic studies. Thimerosal was found to be
significantly more toxic than the other metal compounds examined. Future
studies need to be conducted to evaluate additional mechanisms underlying
Thimerosal-induced cellular damage and assess potential co-exposures to
other compounds that may increase or decrease Thimerosal-mediated toxicity. 


Keywords: autism; glial; lead; mercury; mercuric; neurodevelopmental 


view references (47)
<http://www.informaworld.com/smpp/content~content=a910652305~db=all~jumptype
=rss?tab=references> 

 

 

 

 

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