Blender is an example of a free software that is distributed as a single binary (for a given architecture) which works on most GNU distributions, and is very easy to install. I think most people who frequently use Blender install it via the binaries from the Blender's web site. That's because Blender is developed very rapidly.

On a side note, Blender also comes with a game engine which can be used to develop games relatively easy. A binary of a game done with Blender can also be executed with ease on most GNU distributions.

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