If the purpose deals with science (explaining clearly) more than with marketing (being attractive) then you may like LaTeX beamerposter. Here is an example: http://dcc.ufmg.br/~lcerf/publications/posters/A%20Lossless%20Data%20Reduction%20for%20Mining%20Constrained%20Patterns%20in%20n-ary%20Relations.pdf

If you already know LaTeX (or, even better, LateX Beamer), then it probably is the simpler solution. If not, well, it is a whole language to learn...

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