I'm not sure how the ASUS KFSN4-DRE would work, but it would be better to go
that route than System76 from a free software perspective. System76 isn't
concerned about software freedom and your system might not work with Trisquel
or other 100% free systems.. not to mention have parts with non-free
drivers/firmware.
I'm not entirely sure that your experience with low end hardware in the past
is actually comparable to today's low end integrated graphics offerings.
I wouldn't go with skylake though at this point. We're working on a Broadwell
model with Iris Pro graphics now that the CPUs are available. That probably
is your best bet if you ask me.