> guile: warning: failed to install locale
> warning: failed to install locale: Invalid argument

It's possible to get rid of this warning if you find it annoying, but it is 
harmless. I get that warning every time but have never had a problem related to 
it.

> guix package: warning: Consider running 'guix pull' followed by
> 'guix package -u' to get up-to-date packages and security updates.

This is telling you that Guix's package list is out of date. 'guix pull' is 
similar to 'apt update' and 'guix package -u' is similar to apt-upgrade. It's 
probably a good idea to run 'guix pull' before you start installing packages so 
that you don't waste time upgrading them afterward.

> substitute: updating list of substitutes from
> 'https://mirror.hydra.gnu.org'... substitute: updating list of substitutes
> from 'https://mirror.hydra.gnu.org'... 100.0%

If I understand correctly, the substitutes are precompiled binaries. Without 
them Guix would build everything you install from source.

> Downloading 
> https://mirror.hydra.gnu.org/guix/nar/gzip/9ih7h3qzmvp6pxy2cmqk9cirxdv492v0-binutils-cross-boot0-2.28...
>  binutils-cross-boot0-2.28  21.4MiB   58KiB/s 00:04 [                  ]
> 1.1%
> why downloading various packages instead of installing or removing software?

Packages need to be downloaded in order to be installed, but I'm not sure why 
one is being downloaded when you are *removing* a package.

Apart from these messages, have you run into any problems with the packages 
you've installed through Guix? Most of them look like warnings that shouldn't 
prevent Guix from working, although I do recommend running 'guix pull'.

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