For me some times helpful run several times this command:
 sudo /etc/init.d/vboxdrv setup

First attempt usually fail. but several repeats usually helpful. 
If this command will finish successfully don't reboot and use virtualbox.

-- 
vboxdrv occasionally fails to load on karmic 2.6.30 kernels due to active 
nmi_watchdog
https://bugs.launchpad.net/bugs/399732
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