Ok, just to summarize what you have already done in a previous bug report.
Please correct if any of this is wrong:
checked alsamixer settings.
tried muting the IEC958 device
installed 'linux-backports-modules-alsa-karmic-generic'
Have you checked for the slmodemd daemon to see if it is running?
Run this command again while trying to play something: sudo fuser -v
/dev/dsp* /dev/snd/* /dev/seq*
** Changed in: ubuntu
Status: New => Incomplete
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[karmic] Sound disappears on 82801I Audio (Thinkpad X200 and T400) after updates
https://bugs.launchpad.net/bugs/481759
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