I assume the mouse is plugged in?
Seriously, we need more info to see what the cause of this is:
Have you checked that in /proc/interrupts your mouse is set and configured 
correctly?
Is the relevant module loaded (cat /proc/modules | grep psmouse)?
Is any relevant error/warning reported in the xorg log file 
(/var/log/Xorg.0.log)?
Can you cut and paste here the relevant InputDevice and the ServerLayout 
sections of your xorg.conf?

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my mouse dont work
https://launchpad.net/bugs/91330

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