The following workaround seems to have done the trick for me:
System: Ubuntu 10.04 amd64
File: /etc/pulse/default.pa
Add " tsched=0" to the following line:
load-module module-detect
See post #39 in this thread:
http://ubuntuforums.org/showthread.php?t=1471262
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sound stops and begins clicking and popping
https://bugs.launchpad.net/bugs/476652
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