Me too... strace attached to running process provided the following,
usually only seen after thunderbird had been running for a bit (a few
hours)...

read(3, 0x7f5b97573074, 4096)           = -1 EAGAIN (Resource temporarily 
unavailable)
poll([{fd=4, events=POLLIN}, {fd=3, events=POLLIN}, {fd=8, 
events=POLLIN|POLLPRI}, {fd=12, events=POLLIN|POLLPRI}, {fd=13, 
events=POLLIN|POLLPRI}, {fd=14, events=POLLIN|POLLPRI}, {fd=18, events=POLLIN}, 
{fd=10, events=POLLIN|POLLPRI}, {fd=32, events=POLLIN}, {fd=68, events=POLLIN}, 
{fd=19, events=POLLIN}], 11, 0) = 0 (Timeout)
write(20, "\372", 1)                    = 1
read(3, 0x7f5b97573074, 4096)           = -1 EAGAIN (Resource temporarily 
unavailable)
poll([{fd=4, events=POLLIN}, {fd=3, events=POLLIN}, {fd=8, 
events=POLLIN|POLLPRI}, {fd=12, events=POLLIN|POLLPRI}, {fd=13, 
events=POLLIN|POLLPRI}, {fd=14, events=POLLIN|POLLPRI}, {fd=18, events=POLLIN}, 
{fd=10, events=POLLIN|POLLPRI}, {fd=32, events=POLLIN}, {fd=68, events=POLLIN}, 
{fd=19, events=POLLIN}], 11, 0) = 1 ([{fd=19, revents=POLLIN}])
read(19, "\372", 1)                     = 1
read(3, 0x7f5b97573074, 4096)           = -1 EAGAIN (Resource temporarily 
unavailable)
poll([{fd=4, events=POLLIN}, {fd=3, events=POLLIN}, {fd=8, 
events=POLLIN|POLLPRI}, {fd=12, events=POLLIN|POLLPRI}, {fd=13, 
events=POLLIN|POLLPRI}, {fd=14, events=POLLIN|POLLPRI}, {fd=18, events=POLLIN}, 
{fd=10, events=POLLIN|POLLPRI}, {fd=32, events=POLLIN}, {fd=68, events=POLLIN}, 
{fd=19, events=POLLIN}], 11, 0) = 0 (Timeout)

:~$ lsb_release -a
No LSB modules are available.
Distributor ID: Ubuntu
Description:    Ubuntu 10.04.1 LTS
Release:        10.04
Codename:       lucid
:~$ uname -a
Linux behemoth 2.6.32-25-generic #45-Ubuntu SMP Sat Oct 16 19:52:42 UTC 2010 
x86_64 GNU/Linux

Disabling assorted plugins seemed to help alleviate, but not fix
altogether, I still have extensions check&send, quicktext and the
standard addon for openoffice. using default theme

-- 
100% CPU usage on exit
https://bugs.launchpad.net/bugs/612907
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