I was able to solve this in my case. It appears to be a permissions issue.
 I opened nautilus as root by running "sudo nautilus" from the command line. I 
navigated to 
Home/user/.config
I then right-clicked on .libreoffice and selected "Properties"
I selected the "permissions" tab on top
I set the group and owner as myself (username)
Folder Access - Create and Delete Files
File Access - Read and Write
I selected "Apply permissions to enclosed files" on the bottom
I also did this for the libreoffice subfolders "3" and "user"
I was then able to run it from the desktop.

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https://bugs.launchpad.net/bugs/792947

Title:
  The application cannot be started.  A general error occurred while
  accessing your central configuration.

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