Got the same problem. Tried to delete old kernel-images (3.2.0.29 and
3.2.0.30), then got the error message:

E: Der dpkg-Prozess wurde unterbrochen; Sie müssen manuell »sudo dpkg 
--configure -a« ausführen, um das Problem zu beheben.
E: _cache->open() failed, please report.


Restarting Synaptic fails with the same error message. Removing all files in 
/var/lib/apt/lists/ fails with the following error message:

rm: Entfernen von
»lists/de.archive.ubuntu.com_ubuntu_dists_precise_main_i18n_Index“ nicht
möglich: Eingabe-/Ausgabefehler


After that, running ls in /var/lib/apt/lists/ stucks and can't be aborted via 
CMD+C. Running sudo apt-get update gives no output.

** Tags added: amd64 precise

** Summary changed:

- Crasch Starting : E:_cache->open()failed, please report
+ Crash Starting : E:_cache->open()failed, please report

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https://bugs.launchpad.net/bugs/775458

Title:
  Crash Starting : E:_cache->open()failed, please report

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