I get the same problem. Random mouse lock ups, the keyboard satys responsive. 
Not every day, but enough to be annoying. Loging out doesn't help, neither does 
killing off Lightdm and restarting it. 
Only fix I have found so far is a reboot.

I use a USB keyboard with an adaptor to the PS/2 port.
Fresh install
UI Unity
Linux 3.8.0-19-generic #30-Ubuntu SMP Wed May 1 16:35:23 UTC 2013 x86_64 x86_64 
x86_64 GNU/Linux
Video : Catalyst (but had same trouble with stock driver)
Architecture: x86_64

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https://bugs.launchpad.net/bugs/1167097

Title:
  The mouse stops working randomly and have to reset

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