Debian Sid, the same bug:

(gtk-update-icon-cache:10455): GdkPixbuf-WARNING **: Cannot open pixbuf
loader module file '/usr/lib/i386-linux-gnu/gdk-
pixbuf-2.0/2.10.0/loaders.cache': File o directory non esistente

This likely means that your installation is broken.
Try running the command
  gdk-pixbuf-query-loaders > 
/usr/lib/i386-linux-gnu/gdk-pixbuf-2.0/2.10.0/loaders.cache
to make things work again for the time being.

##############################################################

Package: libgdk-pixbuf2.0-0
Source: gdk-pixbuf
Version: 2.28.1-1
Installed-Size: 519
Maintainer: Debian GNOME Maintainers 
<[email protected]>
Architecture: i386
Replaces: libgtk2.0-0 (<< 2.21.3), libgtk2.0-bin (<< 2.21.3)
Depends: libc6 (>= 2.11), libglib2.0-0 (>= 2.34.0), libjasper1, libjpeg8 (>= 
8c), libpng12-0 (>= 1.2.13-4), libtiff4 (>> 3.9.5-3~), libx11-6, 
libgdk-pixbuf2.0-common (= 2.28.1-1)
Pre-Depends: multiarch-support
Breaks: libgtk2.0-0 (<< 2.21.3), libgtk2.0-bin (<< 2.21.3), librsvg2-2 (<< 
2.26.3-2), libwmf0.2-7 (<< 0.2.8.4-7)
Description-it: libreria GDK Pixbuf
 La libreria GDK Pixbuf fornisce:
  - funzionalità per caricare e salvare immagini;
  - veloce ridimensionamento e composizione di pixbuf;
  - caricamento di semplici animazioni (cioè GIF animate).
Multi-Arch: same
Homepage: http://www.gtk.org/
Description-md5: 63eb319f3f676573afbb3b5585491e65
Tag: implemented-in::c, role::shared-lib
Section: libs
Priority: optional
Filename: pool/main/g/gdk-pixbuf/libgdk-pixbuf2.0-0_2.28.1-1_i386.deb
Size: 158988
MD5sum: c9889352c5f20ef6f172cf1d78b6c3e6
SHA1: fdf59f52f0af312fc883d46f773e9ee8080a912b
SHA256: 10aa35f8fe9eb3316ad43766ef2d3c9a7b492e1612dcff4892bbd93290b53146

-- 
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Bugs, which is subscribed to Ubuntu.
https://bugs.launchpad.net/bugs/911622

Title:
  [12.04] GdkPixbuf-WARNING **: Cannot open pixbuf loader module file
  '/usr/lib/i386-linux-gnu/gdk-pixbuf-2.0/2.10.0/loaders.cache': Datei
  oder Verzeichnis nicht gefunden (file not found)

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