Thanks for your bug report, more information is needed.

What brand and model is your keyboard and mouse?
How is your keyboard and mouse connected to your PC: PS/2, USB, USB wireless 
(Bluetooth), ...
For a USB keyboard or mouse include the output of the command lsusb on a 
terminal.
What mechanism does your mouse use: ball mouse, optical, trackball, ...
How many physical buttons and scrollwheels does you mouse have?

Try the following:
1. Direct after gnome login open a terminal and enter the following command:
  $ cp /var/log/Xorg.0.log ~/Xorg.0.log
  $ cp /var/log/dmesg ~/dmesg_boot
2. Wait until your mouse and keyboard stop working.
3. Open a terminal by pressing Ctrl-Alt-F1.
4. Enter the following commands:
  $ LANG=C
  $ cp /var/log/Xorg.0.log ~/Xorg.0.log_tmp
  $ diff -ns ~/Xorg.0.log ~/Xorg.0.log_tmp > ~/Xorg.0.log_diff-ns
  $ dmesg > ~/dmesg
  $ diff -ns ~/dmesg_boot ~/dmesg > ~/dmesg_diff-ns
5. Attach Xorg.0.log, Xorg.0.log_diff-ns, dmesg_boot and dmesg_diff-ns to this 
bug report.

** Changed in: Ubuntu
     Assignee: (unassigned) => Pascal De Vuyst
       Status: New => Incomplete

-- 
Suddenly unable to use keyboard and use menu's in application+
https://bugs.launchpad.net/bugs/127015
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