I have a similar issue on Ubuntu. Communicating with a /dev/ttyUSB
device works with minicom, but it doesn't with PySerial with the same
settings. It works for about 20% of the time, while other times it
messes with the data, or it hangs indefinitelly/until timeout.

There doesn't seem to be any development regarding this bug for the past
few years.

The solution from billmania didn't work for me, my device requires no
flow control whatsoever.

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https://bugs.launchpad.net/bugs/543331

Title:
  pyserial not communicating with /dev/ttyUSB0

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