Hello! I'm not a Ubuntu pro user, but I'm trying to learn more and more.
Yesterday, I experienced the same situation as described here.

I work with molecular dynamics simulation, specifically with a program
called GROMACS. When I was trying to do a simulation, the program told
me it would take about 2 days to complete (weird, because the kind of
simulation I had trying usually lasts about 6 hours). It only took a
little time for my hard disk free space had being completely consumed
(and breaking my simulation).

When I used the Baobap to see the disk usage, it took me to this folder
.cache/upstart occupying about 70GB! I deleted it, restarted the
computer, and my simulation had functioned normally (it took 5 hours to
complete), and I didn't have any problems with the .cache. Very strange
bug!!

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https://bugs.launchpad.net/bugs/1240848

Title:
  ~/.cache/upstart takes up around 70GB of space due to unity and
  mediascanner

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