Thanks Mark , upgrade of libssl1.0.0 fixed the issue of ntp.
dpkg -l | grep libssl1
ii libssl1.0.0 1.0.1-4ubuntu5.38
SSL shared libraries
dpkg -l | grep openssl
ii openssl 1.0.1-4ubuntu5.38
Secure Socket Layer (SSL) binary and related cryptographic tools
dpkg -l | grep ntp
ii ntp 1:4.2.6.p3+dfsg-1ubuntu3.11
Network Time Protocol daemon and utility programs
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https://bugs.launchpad.net/bugs/1630877
Title:
1:4.2.6.p3+dfsg-1ubuntu3.11 - OPENSSL_1.0.0 not defined in file
libcrypto.so.1.0.0
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