Same issue ...
When happens dmesg results are below ...

[  838.102411] irq 16: nobody cared (try booting with the "irqpoll" option)
[  838.102418] CPU: 3 PID: 0 Comm: swapper/3 Not tainted 4.4.0-45-generic 
#66-Ubuntu
[  838.102421] Hardware name:                  /DQ45CB, BIOS 
CBQ4510H.86A.0133.2011.0810.1010 08/10/2011
[  838.102423]  0000000000200086 816a872290fe3941 ffff88012bd83e60 
ffffffff813f1fe3
[  838.102427]  ffff8800c5952600 ffff8800c59526b4 ffff88012bd83e88 
ffffffff810dd7a3
[  838.102430]  ffff8800c5952600 0000000000000000 0000000000000010 
ffff88012bd83ec0
[  838.102433] Call Trace:
[  838.102435]  <IRQ>  [<ffffffff813f1fe3>] dump_stack+0x63/0x90
[  838.102446]  [<ffffffff810dd7a3>] __report_bad_irq+0x33/0xc0
[  838.102449]  [<ffffffff810ddb37>] note_interrupt+0x247/0x290
[  838.102452]  [<ffffffff810dadc7>] handle_irq_event_percpu+0x167/0x1d0
[  838.102455]  [<ffffffff810dae6e>] handle_irq_event+0x3e/0x60
[  838.102457]  [<ffffffff810de0a6>] handle_fasteoi_irq+0x96/0x150
[  838.102461]  [<ffffffff810310fa>] handle_irq+0x1a/0x30
[  838.102465]  [<ffffffff8183429b>] do_IRQ+0x4b/0xd0
[  838.102469]  [<ffffffff81832382>] common_interrupt+0x82/0x82
[  838.102470]  <EOI>  [<ffffffff816c4dce>] ? cpuidle_enter_state+0x10e/0x2b0
[  838.102477]  [<ffffffff816c4fa7>] cpuidle_enter+0x17/0x20
[  838.102481]  [<ffffffff810c4112>] call_cpuidle+0x32/0x60
[  838.102483]  [<ffffffff816c4f83>] ? cpuidle_select+0x13/0x20
[  838.102486]  [<ffffffff810c43d0>] cpu_startup_entry+0x290/0x350
[  838.102489]  [<ffffffff810516e4>] start_secondary+0x154/0x190
[  838.102491] handlers:
[  838.102495] [<ffffffff816157a0>] usb_hcd_irq
[  838.102528] [<ffffffffc022fdb0>] radeon_driver_irq_handler_kms [radeon]
[  838.102530] Disabling IRQ #16

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https://bugs.launchpad.net/bugs/1572780

Title:
  Keyboard and mouse not responding after locking

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