I have the same issue (Kubuntu 16.10 + Backports). I solved it by installing the "dnsmasq" package.
I had only "dnsmasq-base" installed. -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1644098 Title: Network Manager + OpenVPN does not respond to DNS server change on second connection attempt To manage notifications about this bug go to: https://bugs.launchpad.net/dnsmasq/+bug/1644098/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs