Are you running any virus scanner like Sophos? I had the same issue (the
file that failed was different each time).

I disabled sophos by running 
# sudo /opt/sophos-av/bin/savdctl disable

before running apt.

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https://bugs.launchpad.net/bugs/1673333

Title:
  package linux-headers-4.8.0-42 4.8.0-42.45 failed to install/upgrade:
  unable to open '/usr/src/linux-headers-4.8.0-42/arch/blackfin/mach-
  bf548/include/mach/defBF547.h.dpkg-new': Operation not permitted

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