this problem is happenning to me as well, not only on ubuntu vm but also on 
centos vm.
restart to the vm solves the problem.
but it seems to me like a virtual box issue.
i first thought it was only inside pycharm, and tried the following workaround:
http://youtrack.jetbrains.com/issue/IDEA-78860

# ---------------------------------------------------------------------
# Run the IDE.
# ---------------------------------------------------------------------

# Workaround to prevent keyboard input from being blocked by IBus
XMODIFIERS=""
export XMODIFIERS  

Add these lines after the Run the IDE. In the pycharm.sh

but it happened again...

hope this will help.

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https://bugs.launchpad.net/bugs/1316873

Title:
  Left mouse button stops working

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