Thank you Cas. 
Let me answer to your suggestions.

Check all updates are installed? Try proposed updates? 
I always install all updates.

Is this with mouse or trackpad? 
I only use the trackpad.

Have you checked what gsettings is reporting?

    gsettings get org.gnome.desktop.peripherals.mouse left-handed
    true

Perhaps try a booting with a livecd ubuntu and test mouse there. I don't
have a CD with Ubuntu 18.04.

I started using Ubuntu with version 12.04 and I have updated it to
versions 14.04 and 16.04. The left-handed mode always worked fine. A
couple of weeks ago, I was offered to install version 18.04. The bug
started after the installation of this new version. I must say it is
very annoying.

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https://bugs.launchpad.net/bugs/1758306

Title:
  Cannot switch mouse primary button to Right (left-handed) in Settings

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