Removing the timidity package resolved this for me.

But the symptoms are strange: 
Symptoms after upgrading from 18.04 to 18:10:
- aplay -l shows all audio devices as expected, including internal on-board 
sound device
- pavucontrol only shows hdmi3 output, analog sound is missing from options

Removing timidity (just out of frustration because I couldn't find any
other suggestions on this) and rebooting once brought back the analog
sound devices

Thanks to JR for mentioning this.

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https://bugs.launchpad.net/bugs/1797714

Title:
  [Dell Studio 1557] No sound after upgrade to Kubuntu 18.10 beta

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