I am seeing this bug on a ubuntu 16.04 box running on proxmox 5.1.
Running 4.4.0-72-generic x86_64 guest (linux-image-4.4.0-72-generic).

Under heavy I/O sometimes the guest get stuck for couple of seconds and this 
error is printed:
[538796.529342] hrtimer: interrupt took 37764682 ns

After that the guest becames unbearably slow and only reboot helps.

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https://bugs.launchpad.net/bugs/1346917

Title:
  Using KSM on NUMA capable machines can cause KVM guest performance and
  stability issues

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