I have this issue as well. However, the instructions given in https://bugs.launchpad.net/ubuntu/+source/systemd/+bug/1624320/comments/57 do not solve the issue for me.
When connecting the strongswan VPN, I see that the /run/systemd/resolve/resolv.conf file is touched (the timestamp of the file changes), but the content does not change. Automatic nor manual DNS servers in the VPN settings do not work. I tested manual modifying the /run/systemd/resolve/resolv.conf by changing the nameserver. This works once, but this change is not persisted, as the file is overwritten each time. using fully up to date: Linux myhost 5.4.0-48-generic #52-Ubuntu SMP Thu Sep 10 10:58:49 UTC 2020 x86_64 x86_64 x86_64 GNU/Linux -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1624320 Title: systemd-resolved appends 127.0.0.53 to resolv.conf alongside existing entries To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/systemd/+bug/1624320/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs