Hi,
from your logs:

Error: Unable to shut down server with process id 21763


2020-10-10T05:35:05.369830Z 0 [ERROR] [MY-011292] [Server] Plugin mysqlx 
reported: 'Preparation of I/O interfaces failed, X Protocol won't be accessible'
2020-10-10T05:35:05.370488Z 0 [ERROR] [MY-011300] [Server] Plugin mysqlx 
reported: 'Setup of socket: '/var/run/mysqld/mysqlx.sock' failed, can't create 
lock file /var/run/mysqld/mysqlx.sock.lock'

It reminds me of a different transient issue that occurred to some users in the 
past.
Is this issue reproducible or does it go away on a retry of the package upgrade?

P.S. the reason it is shown "every time" might be due to an upgrade
tried "every time". In that case chances are that a local config change
made it unable to start but a service restart is required for an
upgrade. Was there any config change that could explain that?

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https://bugs.launchpad.net/bugs/1899248

Title:
  package mysql-server-8.0 8.0.21-0ubuntu0.20.04.4 failed to
  install/upgrade: installed mysql-server-8.0 package post-installation
  script subprocess returned error exit status 1

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