>From your log:
2021-01-10T14:01:21.741278Z 0 [ERROR] [MY-011300] [Server] Plugin mysqlx 
reported: 'Setup of socket: '/var/run/mysqld/mysqlx.sock' failed, can't create 
lock file /var/run/mysqld/mysqlx.sock.lock'

That seems like either a duplicate of 
https://bugs.launchpad.net/ubuntu/+source/mysql-8.0/+bug/1899248
or a similar but different (depending on your config) case.

Others had e.g. 
https://askubuntu.com/questions/1263229/error-2002-hy000-cant-connect-to-local-mysql-server-through-socket-var-run
 but in all cases config issues were the reason.

If you get your local config fixed so that it can work with the new
version then upgrades will work again. If you have no particular
interes/data in mysql (e.g. played with it in the past, but no current
need) you can as well just purge the package to get clean upgrades
again.

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https://bugs.launchpad.net/bugs/1910911

Title:
  package mysql-server-8.0 8.0.22-0ubuntu0.20.10.2 failed to
  install/upgrade: installed mysql-server-8.0 package pre-removal script
  subprocess returned error exit status 1

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