I have also observed a similar behavior
with Ubuntu 20.04

lspci | grep Audio

09:00.1 Audio device: Advanced Micro Devices, Inc. [AMD/ATI] Ellesmere HDMI 
Audio [Radeon RX 470/480 / 570/580/590]
0b:00.4 Audio device: Advanced Micro Devices, Inc. [AMD] Starship/Matisse HD 
Audio Controller

uname -a

Linux jrechenknecht7 5.4.0-73-generic #82-Ubuntu SMP Wed Apr 14 17:39:42
UTC 2021 x86_64 x86_64 x86_64 GNU/Linux

and Firefox 88.0.1 (AMD64 Platform).

For me this bug also causes other applications to be distorted, too.

 sudo lshw -C sound

sudo lshw -C sound
  *-usb:4                   
       Beschreibung: Audio-Gerät
       Produkt: HD Webcam C615
       Hersteller: Logitech, Inc.
       Physische ID: a
       Bus-Informationen: usb@1:a
       Version: 0.11
       Seriennummer: 4B9FE1D0
       Fähigkeiten: usb-2.00 audio-control
       Konfiguration: driver=uvcvideo maxpower=500mA speed=480Mbit/s
  *-multimedia
       Beschreibung: Audio device
       Produkt: Ellesmere HDMI Audio [Radeon RX 470/480 / 570/580/590]
       Hersteller: Advanced Micro Devices, Inc. [AMD/ATI]
       Physische ID: 0.1
       Bus-Informationen: pci@0000:09:00.1
       Version: 00
       Breite: 64 bits
       Takt: 33MHz
       Fähigkeiten: pm pciexpress msi bus_master cap_list
       Konfiguration: driver=snd_hda_intel latency=0
       Ressourcen: irq:100 memory:fce60000-fce63fff
  *-multimedia
       Beschreibung: Audio device
       Produkt: Starship/Matisse HD Audio Controller
       Hersteller: Advanced Micro Devices, Inc. [AMD]
       Physische ID: 0.4
       Bus-Informationen: pci@0000:0b:00.4
       Version: 00
       Breite: 32 bits
       Takt: 33MHz
       Fähigkeiten: pm pciexpress msi bus_master cap_list
       Konfiguration: driver=snd_hda_intel latency=0
       Ressourcen: irq:102 memory:fc900000-fc907fff

Note that the behavior occurred when the Logitex C615 has been unplugged.
I was just curious, because Dave Evans has the same webcam so I could not 
exclude that
this may be related.

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https://bugs.launchpad.net/bugs/1906741

Title:
  Firefox sometimes causes garbled audio

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