Sounds like either a faulty mouse or a Xorg-specific bug (the login
screen doesn't use Xorg).
Please try either a new mouse, or selecting 'Ubuntu on Wayland' from the
login screen.
** Package changed: xorg (Ubuntu) => xorg-server (Ubuntu)
** Changed in: xorg-server (Ubuntu)
Status: New => Incomplete
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https://bugs.launchpad.net/bugs/1933003
Title:
left click on USB mouse stops working
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