I had the same problem: mysqd_safe using 100% CPU running wait4() syscall.
The problem started just after I've restarted MySQL, because I've changed the 
configuration file (I've changed bind-address from 127.0.0.1 to 0.0.0.0 in 
/etc/mysql/my.cnf).
I've noticed that  more than one mysql_safe was running. After killall 
mysql_safe and started again the server, everything went back to normal.

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mysqd_safe high cpu usage
https://bugs.launchpad.net/bugs/105457
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