I've got the same problem after upgrading to 2.6.22-14-generic.

The mouse just stops working and I get the following line to dmesg:

usb 1-2.2: device descriptor read/64, error -110

I've put the line

option usbcore old_scheme_first=y

to /etc/modutils/options and haven't got the error again.
After a reboot you can verify, that the usbcore module
now uses the old_scheme_first by running:

cat /sys/module/usbcore/parameters/old_scheme_first

-- 
frozen mouse pointer at login
https://bugs.launchpad.net/bugs/132909
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