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Avocado waves its pro-health banner
http://www.ovcrd.upd.edu.ph/avocado.htm
Folkloric medicine claims that the decoction of avocado leaves is an
effective remedy for arthritis. To test this claim, an investigation of
the anti-inflammatory principles of the fruit would have to be
undertaken, considering that inflammation is a chief pathological sign
of rheumatic diseases.
A research team composed of Amelia Guevara, Ma. Pythias Espino, and
Celeste Chua of the Institute of Chemistry, UP Diliman, undertook this
investigation.
Their study, The Anti-Inflammatory Principles of Persea americana,
Mill., showed that the leaf extracts from Persea americana, familiarly
known as avocado, were found to inhibit inflammatory activities. The
crude ethanol extract reduced inflammation by 75.6% at a dosage of 3
g/kg body weight.
The ethanol was further extracted to give a fraction of hexane, ethyl
acetate, which yielded compounds that were found to have anti-
inflammatory properties. Their curative power comes principally from
their ability to inhibit, or at least cause less, platelet aggregation
that is responsible for producing pro-inflammatory mediators.
>From the hexane fraction was isolated avocadene, a compound which "had
been previously isolated from the seeds and fruit of persea americana
and had been tested for anti-bacterial properties," but whose anti-
inflammatory activity had been reported for the first time. It was
found to have reduced the inflammation induced in test animals (mice)
by 66.3 % at a dosage of 0.2 g/kg body weight.
The compound isolated from the ethyl acetate fraction, on the other
hand, reduced the inflammation by 36.6 % at a dosage of 0.2 g/kg body
weight.
This study reinforces the reputation of avocado as a healing herb by
demonstrating its ability to interfere in inflammatory activity and
increases the number of ailments (diarrhea, dysentery, abdominal pains
and high blood pressure) for which it is said to have curative effects.
2-Hydroxy-4-oxohenicosan-1-yl Acetate. Its Presence in Avocado and its
Simple Chemistry
Raymond M. Carman, Alan R. Duffield, Paul N. Handley and Tomislav
Karoli
Abstract
The title compound (1b) is present in avocado leaves. Simple chemistry
of the compound is described.
Keywords: Avocado; anti-cancer; anti-lactation.
Australian Journal of Chemistry 53(3) 191 - 194
Full text doi:10.1071/CH00040
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bwanika
url: www.idr.co.ug
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