S'cuzez le !
Y'est en mode surfing ces jours-ci

Question :
Je sais qu'il y a beaucoup de complications avec l'spirine
Des milliers de mort annuellement ! (Je retrouve pas l'article)

Mais quand est-il des complicaitons li� � la prise chronique de
microdose (80mg DIE) ?

et

Est-ce sachant que chez nous on �vite depuis longtemps l'AAS le plus
possible (Reyes Syndrome, troubles digestifs, allergies) et quel est
presque compl�tement remplac� par l'entrophen(parac�tamol)
Quant est-il en France ?
(En Alg�rie, y'en prennent encore comme de la soupe (p�diatrie
inclus)


Charles Brault EMT-P


Am J Cardiol. 2002 Mar 15;89(6):653-61.         

Underuse of aspirin in a referral population with documented coronary
artery disease.

Califf RM, DeLong ER, Ostbye T, Muhlbaier LH, Chen A, LaPointe NA,
Hammill BG, McCants CB, Kramer JM.

Centers for Education & Research on Therapeutics (CERTs), Duke
Clinical Research Institute, Durham, North Carolina 27715, USA.
[EMAIL PROTECTED]

Despite substantial evidence that antiplatelet therapy saves lives
and reduces adverse events in patients with coronary artery disease
(CAD), use of the most widely available and lowest cost antiplatelet
agent, aspirin, continues to be disappointingly low. 

In a large database of patients with known CAD, we (1) explored
trends in the use of aspirin over time, (2) characterized patients
most likely to take aspirin regularly, and (3) estimated the
effectiveness of aspirin use by examining long-term outcomes. Using
patients entered in the Duke Databank for Cardiovascular Diseases, we
explored the use of aspirin from 1969 to 1999. 
More than 25,000 patients were sent a questionnaire that included
several questions about medication use, including 1 question
specifically about aspirin. Patients who failed to respond to the
questionnaire received a follow-up telephone call. 

Aspirin use increased substantially over the most recent 4 years in
the study, from 59% in 1995 to 81% in 1999. Predictors of aspirin use
included younger age, male sex, being a nonsmoker, and having had a
myocardial infarction or revascularization procedure. Patients who
never took aspirin had a risk ratio for death of 1.85 compared with
patients who regularly took aspirin. 

Despite the well-known beneficial effects of aspirin, too many
patients without contraindications to aspirin fail to take it
regularly. 

The health care system currently lacks effective methods to ensure
that patients who have CAD have adequate follow-up concerning aspirin
use.



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