BRANCHET-ALLINIEU J Ch a écrit :
Bonjour, des amis "voileux" me demandent de les conseiller au sujet de la
Cinnarizine, non commercialisée en France, sensée être le plus efficace des
anti-mal-des-transports (parole de voileux).
L'un d'entre vous pourrait-il éclairer ma lanterne à ce sujet ?
J. Christophe Branchet-Allinieu
--- URG-L
Pour modifier votre adresse de courriel sur URG-L, envoyez un avis a
[EMAIL PROTECTED] en indiquant votre nouvelle adresse ainsi que
l'ancienne et le nom de la liste.
en fait si ça marche aussi sur les vertiges mais c'est anti H1 sédatif
et bloqueur calcique et pour les vertiges ils semblent privilégier le
sibélium
mais bon prendre un truc sédatif pour aller sur un bateau... autant
rester en chaise longue ;-)
Cinnarizine (not available in USA)
Cinnarizine, not available in the US, is mainly marketed elsewhere as a
H1 antihistamine. It also antagonizes noradrenaline, nicotine and
angiotension, as well as is a calcium channel blocker. Because
Cinnarizine has so many actions, it is difficult to know if positive
affects can be attributed to calcium channel blocking vs. actions at
other receptors. Pianese et al (2002) found Cinnarizine very effective
for peripheral vertigo. Bartual et al (1989) reported cinnarizine plus
dihydroergocristine effective in 90% of 122 patients with vertigo of
cervical origin. As the criteria for the diagnosis of cervical vertigo
are presently very unclear, the meaning of this observation is
uncertain. Doweck et al (1994) found that cinnarizine reduces VOR gain
on rotatory testing. The usual dose is 12.5 mg three times daily.
Sedation is a common side effect. We see no particular reason to use
cinnarizine when flunarizine is available.
Flunarizine (not available in USA)
Flunarizine, also not available in the US, is a fluorinated derivative
of Cinnarizine, which is more potent and has a much longer half-life.
Ell and Gresty (1983) found flunarizine not to reduce vestibular gain,
but rather to reduce or abolish after-nystagmus, and in particular,
abolish secondary phases. There was no effect on pursuit or voluntary
saccades, but vestibular saccades were of lower and more uniform
amplitude. On the other hand, Lee et al (1986) reported flunarizine to
be a "powerful peripherally acting labyrinthine suppressant", in a study
of 10 military personnel. The peak velocity of VOR slow phase was
reduced to approximately 70%, at 2 hours after ingestion. Drowsiness
occurred in about 5%. Oosterveldt (1974) also reported a reduction in
the velocity or rotatory nystagmus. It has also been suggested that
flunarizine may facilitate or accelerate vestibular compensation in
hemilabyrinthectomized guinea pigs (Tolu and Mameli, 1984). These
authors further suggested that flunarizine results in excitation of
cerebellar cortex (1988). The usual dose is 10 mg daily. Flunarizine has
also been used for treatment of Migraine and seems to be a little less
effective than propranolol (Verspeelt et al, 1997). Sedation is a common
side effect, but numerous other side effects are possible. Generally
speaking, medications which are not available in the USA can be obtained
through overseas pharmacies legally, as long as they are for treatment
of an important health problem and only for personal use.
--
JF Pion
booster d'entropie
des montages électroniques pour le modélisme
http://jean.francois.pion.free.fr
le site du vol électrique http://electrofly.free.fr/
--- URG-L
Les archives de la liste d'echange sont disponibles pour consultation
a l'adresse :
<http://webmail.niveau3.ca/public/mail-archives/[email protected]>.
L'acces est protege par mot de passe: usager: archives et mot de
passe: archives
Les archives antérieures sont disponibles a :
<http://www.mail-archive.com/[email protected]>
