Très intéressant, mais si ça augmente les chances de contrôler à la
fois la fréquence et le rythme, ça suggère que l'on puisse risquer de
convertir des FA chroniques, avec les risques associés d'embolie.
On ne devrait logiquement ne s'en servir que dans les FA aigues, en
autant que l'on puisse être certain qu'une FA est aigue
Ou suis-je dans les pommes de terre ? (puisque la France nous lit, je
ne voudrai pas les dérouter avec des termes comme patates)
Michel Garner
On 16-Sep-07, at 5:49 PM, Alain Vadeboncoeur wrote:
Très intéressant.
Am J Cardiol. 2007 Jun 15;99(12):1726-32. Epub 2007 Apr
26.<http---linkinghub.elsevier.com-ihub-images-PubMedLink.gif> Links
Meta-analysis of magnesium therapy for the acute management of rapid
atrial fibrillation.
Onalan O, Crystal E, Daoulah A, Lau C, Crystal A, Lashevsky I.
Arrhythmia Services, Division of Cardiology, Sunnybrook Health
Sciences Centre, University of Toronto, Ontario, Canada.
[EMAIL PROTECTED]
The profile of electrophysiologic effects of magnesium on the heart
suggests that magnesium might be effective in the treatment of atrial
fibrillation (AF) in terms of rhythm and rate control. We aimed to
investigate the efficacy of magnesium administration in the acute
treatment of rapid AF. Randomized controlled trials comparing
intravenous magnesium versus placebo or antiarrhythmic agents for the
acute management of rapid AF were included. Nine electronic databases
were searched for relevant trials from the earliest possible dates
through June 2005, as were abstract books from 8 cardiovascular
meetings held in the past 10 years. We analyzed all outcomes using a
fixed-effect model because of the low number of trials in each
comparison. The results were expressed as relative risks (RRs) or odds
ratios (ORs) for dichotomous outcomes and weighted mean differences
for continuous outcomes, along with their 95% confidence intervals
(CIs). Data were pooled for 4 trials (n=303) and 8 trials (n=476),
respectively, for rate control (<100 beats/min) and rhythm control.
Magnesium was effective in achieving rate control (OR 1.96, 95% CI
1.24 to 3.08) or rhythm control (OR, 1.60, 95% CI 1.07 to 2.39). An
overall response was achieved in 86% and 56% of patients in the
magnesium and control groups, respectively (OR 4.61 95% CI 2.67 to
7.96). Time to response (in hours) was significantly shorter in the
magnesium group (weighted mean difference, -6.98; 95% CI -9.27 to
-4.68). The risk of having a major adverse effect in the magnesium
group was similar to that in the placebo group (RR 0.85, 95% CI 0.44
to 1.61). In conclusion, the present meta-analysis of published data
suggests that intravenous magnesium administration is an effective and
safe strategy for the acute management of rapid AF.
J'avais déjà essayé une fois, il y a longtemps.
Je m'y mets dès cette semaine.
Alain
From: [email protected] [mailto:[EMAIL PROTECTED] On Behalf Of Martin
Chénier
Sent: 16 septembre 2007 15:23
To: [email protected]
Subject: URG-L: Magnésium et FA
Est-ce que certains d'entre vous ont lu l'article suivant :
Meta-Analysis of Magnesium Therapy for the Acute Management of Rapid
Atrial Fibrillation. Am J Cardiol 2007;99:1726-1732.
Utilisez-vous le sulfate de Mg dans la FA/Flutter rapide?
--
Martin Chénier
[EMAIL PROTECTED]
