Prouve ? Ce serait sympa que l'on prouve l'efficacit� d'un m�dicament assez anodin.
Pour la premi�re �tude, le r�sum� ne donne pas les m�thodes. C'est une petite s�rie et je me demande si on peut faire une �tude "d'�quivalence" avec un si petit effectif, avec une puissance suffisante ? Les auteurs ne disent pas dans le r�sum� la rapidit� et intensit� du ralzentissement. Et quelle dose comment ? Tu as les d�tails ? Pour le second, ils disent "cliniquement peu significatif. Donc �a ralenti mais pas beaucoup. Tu as les d�tails ? >Messsage du 08/01/2002 14:17 >De : <[EMAIL PROTECTED]> >A : <[EMAIL PROTECTED]> >Copie � : >Objet : URG-L: Le magn�sium est efficace pour ralentir une FA > > Le magn�sium est efficace pour ralentir une FA (par action de frein sur > le noeud AV). Ces deux r�f�rences le prouvent. Certains d'entre vous > l'utilisent d�j� ? > > 1: Chiladakis JA, Stathopoulos C, Davlouros P, Manolis AS. Intravenous > magnesium sulfate versus diltiazem in paroxysmal atrial fibrillation. > Int J Cardiol 2001 Jul;79(2-3):287-91 > > BACKGROUND: Drugs currently available for the acute treatment of > paroxysmal atrial fibrillation have significant limitations. We assessed > the safety and effectiveness of intravenous magnesium sulfate versus > diltiazem therapy in patients with prolonged episodes of paroxysmal > atrial fibrillation. METHODS: In a prospective randomized trial, 46 > symptomatic patients presenting with paroxysmal atrial fibrillation were > given intravenous magnesium sulfate (n=23) or diltiazem (n=23) therapy. > Primary outcome measures were effects on ventricular rate control and > proportion of patients restored to sinus rhythm at 6 h after initiation > of treatment. RESULTS: There were no differences in baseline > characteristics between the two groups. Both forms of treatment were > well tolerated, with no adverse clinical events. Both drugs had similar > efficacy in reducing the ventricular rate at the first hour of treatment > (P<0.05) with a tendency toward a further decrease during infusion times > of 2 (P<0.01), 3, 4, 5 and 6 h, respectively (P<0.001). However, at the > end of the 6-h treatment period, restoration of sinus rhythm was > observed in a significantly higher proportion of patients in the > magnesium group compared with the diltiazem group [13 of 23 patients, > (57%), versus five of 23 patients, (22%), P=0.03]. CONCLUSIONS: > Magnesium sulfate favorably affects rate control and seems to promote > the conversion of long lasting episodes of paroxysmal atrial > fibrillation to sinus rhythm, representing a safe, reliable and > cost-effective alternative treatment strategy to diltiazem. > > 2: Eur J Emerg Med 2000 Dec;7(4):287-90 Magnesium efficacy in magnesium > deficient and nondeficient patients with rapid ventricular response > atrial fibrillation. Eray O, Akca S, Pekdemir M, Eray E, Cete Y, Oktay > C. > We assessed the effect of magnesium sulphate (MgSO4) on lowering the > rate in ventricular atrial fibrillation (AF), and evaluated the effect > of this therapy in magnesium (Mg) deficient and nondeficient patients. > This experimental clinical study was performed on 34 patients with rapid > AF (ventricular rate [VR] > 120/minute) presenting to the emergency > department of a tertiary care university hospital. Patients with > systolic blood pressure < or = 100 mmHg, Hb level < or = 11.8, saO2 of < > or = 96%, BUN > or = 40 or creatine > or = 1.8 were excluded (n = 15). > Nineteen patients were given an initial 2 g MgSO4 bolus i.v. and a 1 > g/hour continuous infusion over 6 hours. To evaluate the presence of Mg > deficiency, urine was collected from the onset of treatment and > continued for the next 24 hours, and the excretion rate of administered > Mg was calculated. Ventricular rates were obtained at baseline, after > MgSO4 bolus, and every 15 minutes for the first hour. The decrease in > the VR was statistically significant at 15, 30 and 60 minutes after Mg > therapy (p = 0.0025, p < 0.001, p > 0.001). There was no difference in > the response to Mg therapy between Mg deficient and nondeficient > patients at 15, 30 or 60 minutes after therapy (p = 0.41, p = 0.28, p = > 0.08). It is concluded that i.v. MgSO4 has a statistically significant > but clinically limited effect on VR and this effect did not differ > between patients with and without Mg deficiency. > >
