> Could this be related as well to
> https://issues.apache.org/jira/browse/CASSANDRA-2463?

My gut feel: Maybe, if the slowness/timeouts reported by the OP are
intermixed with periods of activity to indicate compacting full gc.

OP: Check if cassandra is going into 100% (not less, not more) CPU
usage during periods of timeouts. If the huge allocations fail due to
fragmentation and fallback to Full GC that might be an expected
result. Else -XX:+PrintGC -XX:+PrintGCDetails -XX:+PrintGCTimeStamps.

-- 
/ Peter Schuller

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