Should be fine, though it will increase disk usage in dc1 for a while - a 
reference to the the cleaned up sstables will be held by the rebuild streams, 
causing you to temporarily increase disk usage until rebuild finishes streaming


-- 
Jeff Jirsa


> On Dec 22, 2017, at 4:30 PM, Peng Xiao <2535...@qq.com> wrote:
> 
> Hi there,
> Can we run nodetool cleanup in DC1,and run rebuild in DC2 against DC1 
> simultaneously?
> in C* 2.1.18
> 
> 
> Thanks,
> Peng Xiao
> 

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