>> Some environment details like Cassandra version, amount of physical RAM, 
JVM configs (heap and others), and any other non-default cassandra.yaaml 
configs would help. The amount of data, number of keyspaces & tables, 
since you mention "clients", would also be helpful for people to suggest 
tuning improvements.

We are more or less using the default properties.
Here are some more details

- Total nodes in the cluster - 9
- Disk for each node is 2 TB
- Number of keyspaces - 1000
- Each keyspace has 5-10 tables
- We observed this problem on a c4.4xlarge (AWS EC2) instance having 30GB RAM 
with 8GB heap
- We observed the same problem on a c4.8xlarge having 60GB RAM with 12GB heap


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