We have been running 5.4.0 in production for a few weeks and it can easily 
handle tens of thousands of messages a day, but then for no apparent reason it 
will cease accepting new messages from our producers.  The consumers will drain 
the queue empty, but then nothing new gets accepted into Active MQ.  Restarting 
Active MQ and then restarting all the producers and consumers allows things to 
proceed as normal.
  Below is our activemq.xml.
  Thanks for any help.
   -M@

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<beans
  xmlns="http://www.springframework.org/schema/beans";
  xmlns:amq="http://activemq.apache.org/schema/core";
  xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance";
  xsi:schemaLocation="http://www.springframework.org/schema/beans 
http://www.springframework.org/schema/beans/spring-beans-2.0.xsd
  http://activemq.apache.org/schema/core 
http://activemq.apache.org/schema/core/activemq-core.xsd";>

    <!-- Allows us to use system properties as variables in this configuration 
file -->
    <bean 
class="org.springframework.beans.factory.config.PropertyPlaceholderConfigurer">
        <property name="locations">
            <value>file:${activemq.base}/conf/credentials.properties</value>
        </property>      
    </bean>

    <!-- 
        The <broker> element is used to configure the ActiveMQ broker. 
    -->
    <broker xmlns="http://activemq.apache.org/schema/core"; 
brokerName="localhost" dataDirectory="${activemq.base}/data" 
destroyApplicationContextOnStop="true">
 
        <!--
                        For better performances use VM cursor and small memory 
limit.
                        For more information, see:
            
            http://activemq.apache.org/message-cursors.html
            
            Also, if your producer is "hanging", it's probably due to producer 
flow control.
            For more information, see:
            http://activemq.apache.org/producer-flow-control.html
        -->
              
        <destinationPolicy>
            <policyMap>
              <policyEntries>
                <policyEntry topic=">" producerFlowControl="false" 
memoryLimit="100mb">
                  <pendingSubscriberPolicy>
                    <vmCursor />
                  </pendingSubscriberPolicy>
                </policyEntry>
                <policyEntry queue=">" producerFlowControl="true" 
memoryLimit="1mb">
                  <!-- Use VM cursor for better latency
                       For more information, see:
                       
                       http://activemq.apache.org/message-cursors.html
                       
                  <pendingQueuePolicy>
                    <vmQueueCursor/>
                  </pendingQueuePolicy>
                  -->
                </policyEntry>
              </policyEntries>
            </policyMap>
        </destinationPolicy> 
 
        
        <!-- 
            The managementContext is used to configure how ActiveMQ is exposed 
in 
            JMX. By default, ActiveMQ uses the MBean server that is started by 
            the JVM. For more information, see: 
            
            http://activemq.apache.org/jmx.html 
        -->
        <managementContext>
            <managementContext createConnector="false"/>
        </managementContext>

        <!-- 
            Configure message persistence for the broker. The default 
persistence
            mechanism is the KahaDB store (identified by the kahaDB tag). 
            For more information, see: 
            
            http://activemq.apache.org/persistence.html 
        -->
        <persistenceAdapter>
            <kahaDB directory="${activemq.base}/data/kahadb"/>
        </persistenceAdapter>
        
        
          <!--
            The systemUsage controls the maximum amount of space the broker 
will 
            use before slowing down producers. For more information, see:
            
            http://activemq.apache.org/producer-flow-control.html
             
        <systemUsage>
            <systemUsage>
                <memoryUsage>
                    <memoryUsage limit="100 mb"/>
                </memoryUsage>
                <storeUsage>
                    <storeUsage limit="10 gb"/>
                </storeUsage>
                <tempUsage>
                    <tempUsage limit="100 mb"/>
                </tempUsage>
            </systemUsage>
        </systemUsage>
                -->
                  
        <!-- 
            The transport connectors expose ActiveMQ over a given protocol to
            clients and other brokers. For more information, see: 
            
            http://activemq.apache.org/configuring-transports.html 
        -->
        <transportConnectors>
            <transportConnector name="openwire" uri="tcp://0.0.0.0:61616"/>
        </transportConnectors>

    </broker>

    <!-- 
        Uncomment to enable Camel
        Take a look at activemq-camel.xml for more details
         
    <import resource="camel.xml"/>
    -->

    <!-- 
        Enable web consoles, REST and Ajax APIs and demos
        Take a look at activemq-jetty.xml for more details 
    -->
    <import resource="jetty.xml"/>
    
</beans>

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