thanks for the tips! Based on these, this seams to be the easiest way:
var txt : String =
"11111\n222222222222222\t333\t44444444\t555555\n66666\t77777777\t88\t99999\naaaa\tbbbbbbbb\tcccccccc\tddd";
txtBox.text = txt;
txtBox.setStyle("tabStops", "e200 c250 s300");
<s:RichText id="txtBox" top="25" left="25" width="600" height="200" />
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